People who stop using weight-loss injections regain lost weight in under two years, a major study shows.
Researchers from the University of Oxford analysed data from 37 studies involving over 9,000 participants.
The drugs, known as GLP-1 agonists, were originally developed to treat diabetes.
Participants regained weight at an average rate of 0.4kg per month after stopping medication.
Most returned to their original weight within about 1.7 years.
Weight regain was almost four times faster than after behavioural weight-loss programmes.
Cardio-metabolic benefits, including lower blood pressure and cholesterol, also reversed after stopping treatment.
The findings were published in the BMJ.
Experts say obesity is a chronic condition requiring long-term management, not short-term drug use.
The NHS stressed weight-loss drugs must be combined with lifestyle and behavioural support.
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